Endocrine Abstracts

The factors affecting counterregulatory (CR) responses to hypoglycaemia in T2DM remain uncertain. Previous studies have suggested an effect of glycaemic control on CR responses in T2DM. Little data exists on the effect of treatment with metformin (MET) vs. Sulphonylurea (SUL) on the CR responses to hypoglycaemia in T2DM.To date, we have performed stepped hypoglycaemic hyperinsulinaemic clamp studies (2-4 mU/kg/min) on 5 subjects treated with MET (Age 50....

Crooke Cell Adenoma (CCA) is a rare variant of ACTH-secreting corticotroph adenoma. Its importance derives from its aggressive behaviour, association with Cushings Disease and differentiation from metastatic carcinoma. A sixty-year old shopkeeper presented with a two-year history of generalised aches and pains, proximal muscle weakness, increased facial hair and easy bruising. She had also noticed an increased abdominal girth and facial rotundity. There was an eight-year histo...

A 35 year old steel worker with a background of congenital adrenal hyperplasia (CAH) presented with a six month history of bilateral testicular swellings. CAH was diagnosed at 2 weeks of age. He was discharged from the paediatric service at 18 years and remained on an unchanged of hydrocortisone 10mg BD and fludrocortisone 0.25mg OD from that time. Two younger male siblings, of equal stature, and a nephew of 18 months were unaffected. He was normotensive, final height 5 8, wit...

A 28 years old lady presented at 21 weeks gestation with bipedal oedema and 4 week history of easy bruising and weakness and aching of the thighs. She had no significant past medical history and had prior uneventful pregnancy 17 months previously. On examination she was hypertensive (180/100 mmHg), had puffy face, prominent abdominal striae and bilateral leg oedema. Serum potassium was 2.6 mmol/l and random plasma glucose was 8.6 mmol/l. OGTT confirmed gestational diabetes and...

All adolescent and young adult T1DM attending our clinic, based in a university teaching hospital are reviewed three monthly and receive individual advice from dietician, nurse educator and consultant diabetologist at each visit. We aimed to identify deficits in diabetes related knowledge and assess diabetic control in this population.Subjects were asked to complete ADKnowl(Audit of Diabetes Knowledge) Questionnaire. Demographic data and measures of glyc...